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Article

Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.

Molecular and cellular biochemistry - 1 Jan 2011

Akkız Hikmet, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin, Ülger Yakup

Abstract excerpt

Cyclooxygenase-2 (COX-2) influences carcinogenesis through immune response suppression, apoptosis inhibition, regulation of angiogenesis and tumor cell invasion, and metastasis. It is now well established that COX-2 is overexpressed in many premalignant, malignant, and metastatic cancers, including hepatocellular carcinoma (HCC). DNA sequence variations in the COX-2 gene may lead to altered COX-2 production...

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PMID: 21042835
DOI: 10.1007/s11010-010-0629-9

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