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Article

Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.

Carcinogenesis - 1 Jun 2007

Tan Wen, Wu Jianxiong, Zhang Xuemei, Guo Yongli, Liu Junniao, Sun Tong, Zhang Bailin, Zhao Dan, Yang Ming, Yu Dianke, Lin Dongxin

Abstract excerpt

Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis. Genetic polymorphisms in COX-2 and 12-LOX might therefore affect susceptibility to colorectal cancer (CRC). To examine this hypothesis, genotypes of COX-2 -1290A>G, -1195G>A, -765G>C and 12-LOX 261Arg>Gln polymorphisms were determined in 1000 CRC patients and 1300 controls. Increased risk of...

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PMID: 17151091
DOI: 10.1093/carcin/bgl242

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LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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