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Article

COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention.

European journal of gastroenterology & hepatology - 1 May 2010

Pereira Carina, Pimentel-Nunes Pedro, Brandão Catarina, Moreira-Dias Luís, Medeiros Rui, Dinis-Ribeiro Mário

Abstract excerpt

OBJECTIVE: COX-2, the inducible isoenzyme, was found to be overexpressed in approximately 85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 polymorphisms that might modify the levels of protein expression would be anticipated to have a substantial influence on disease phenotype. Therefore, we sought to understand the role of three COX-2 polymorphisms (-1195A>G, -765G>C, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20075740
DOI: 10.1097/MEG.0b013e3283352cbb

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