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Article

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.

Cell - 7 Mar 2008

Carballo Jesús A, Johnson Anthony L, Sedgwick Steven G, Cha Rita S

Abstract excerpt

An essential feature of meiosis is interhomolog recombination whereby a significant fraction of the programmed meiotic double-strand breaks (DSBs) is repaired using an intact homologous non-sister chromatid rather than a sister. Involvement of Mec1 and Tel1, the budding yeast homologs of the mammalian ATR and ATM kinases, in meiotic interhomlog bias has been implicated, but the mechanism remains elusive. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18329363
DOI: 10.1016/j.cell.2008.01.035

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.PMID 18329363Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

Hop1 and the meiotic DNA-damage response.Semantic proximity Read ↗

Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.Semantic proximity Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.Semantic proximity Read ↗

The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in Arabidopsis thaliana.Semantic proximity Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response.Semantic proximity Read ↗

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.Semantic proximity Read ↗

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