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Article

RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

Cancer research - 15 Aug 2013

Danussi Carla, Akavia Uri David, Niola Francesco, Jovic Andreja, Lasorella Anna, Pe'er Dana, Iavarone Antonio

Abstract excerpt

Mesenchymal transformation is a hallmark of aggressive glioblastoma (GBM). Here, we report the development of an unbiased method for computational integration of copy number variation, expression, and mutation data from large datasets. Using this method, we identified rhophilin 2 (RHPN2) as a central genetic determinant of the mesenchymal phenotype of human GBM. Notably, amplification of the human RHPN2 gene on...

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Source

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Identifiers

PMID: 23774217
DOI: 10.1158/0008-5472.CAN-13-1168-T
PMCID: PMC3805507

Genes

RHPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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