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Article

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2024

Xu Chenxin, Chen Guoyu, Yu Bo, Sun Bowen, Zhang Yingwen, Zhang Mingda, Yang Yi, Xiao Yichuan, Cheng Shi-Yuan, Li Yanxin, Feng Haizhong

Abstract excerpt

The factors driving glioma progression remain poorly understood. Here, the epigenetic regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 overexpression promotes HRasV12 anaplastic astrocytoma (AA) progression into epithelioid GBM (Ep-GBM)-like tumors. Co-transfection of TRIM24 with HRasV12 also induces Ep-GBM-like transformation of human neural stem cells (hNSCs) with tumor protein p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38828688
DOI: 10.1002/advs.202400023
PMCID: PMC11304257

Genes

TRIM24
PHAX
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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