Article

HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide

2023-06-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The origin and genesis of highly malignant and heterogenous glioblastoma brain tumors remain unknown. We previously identified an enhancer-associated long non-coding RNA, LINC01116 (named HOXDeRNA here), that is absent in the normal brain but is commonly expressed in malignant glioma. HOXDeRNA has a unique capacity to transform human astrocytes into glioma-like cells. This w...

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Literature Corpus work: d703f5a7-fa7e-5bf9-8b2b-3a188bd00cf7
DOI: 10.1101/2023.06.30.547275

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