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Article

Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.

Nature communications - 28 Nov 2024

Myers Bianca L, Brayer Kathryn J, Paez-Beltran Luis E, Villicana Estrella, Keith Matthew S, Suzuki Hideaki, Newville Jessie, Anderson Rebekka H, Lo Yunee, Mertz Conner M, Kollipara Rahul K, Borromeo Mark D, Lu Q Richard, Bachoo Robert M, Johnson Jane E, Vue Tou Yia

Abstract excerpt

Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription factors ASCL1 and OLIG2 are dynamically co-expressed in GBMs; however, their combinatorial roles in regulating the plasticity and heterogeneity of GBM cells are unclear. Here, we show that induction of somatic mutations in subventricular...

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Identifiers

PMID: 39609428
DOI: 10.1038/s41467-024-54750-9
PMCID: PMC11605073

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