Article
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.
Cancer cell - 9 May 2016
Lu Fanghui, Chen Ying, Zhao Chuntao, Wang Haibo, He Danyang, Xu Lingli, Wang Jincheng, He Xuelian, Deng Yaqi, Lu Ellen E, Liu Xue, Verma Ravinder, Bu Hong, Drissi Rachid, Fouladi Maryam, Stemmer-Rachamimov Anat O, Burns Dennis, Xin Mei, Rubin Joshua B, Bahassi El Mustapha, Canoll Peter, Holland Eric C, Lu Q Richard
Abstract excerpt
Malignant gliomas exhibit extensive heterogeneity and poor prognosis. Here we identify mitotic Olig2-expressing cells as tumor-propagating cells in proneural gliomas, elimination of which blocks tumor initiation and progression. Intriguingly, deletion of Olig2 resulted in tumors that grow, albeit at a decelerated rate. Genome occupancy and expression profiling analyses reveal that Olig2 directly activates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.