Article
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary.
Nature communications - 2 Jan 2020
Kim Sarah H, Da Cruz Paula Arnaud, Basili Thais, Dopeso Higinio, Bi Rui, Pareja Fresia, da Silva Edaise M, Gularte-Mérida Rodrigo, Sun Zhen, Fujisawa Sho, Smith Caitlin G, Ferrando Lorenzo, Martins Sebastião Ana Paula, Bykov Yonina, Li Anqi, Silveira Catarina, Ashley Charles W, Stylianou Anthe, Selenica Pier, Samore Wesley R, Jungbluth Achim A, Zamarin Dmitriy, Abu-Rustum Nadeem R, Helin Kristian, Soslow Robert A, Reis-Filho Jorge S, Oliva Esther, Weigelt Britta
Abstract excerpt
Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (4/26) SSTs, none of which are detected in other types of SCSTs (n = 48) or common cancer types...
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