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Article

The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.

Cancer letters - 10 Jul 2016

Kaur Harpreet, Ali Sabeen Zulfiqar, Huey Lauren, Hütt-Cabezas Marianne, Taylor Isabella, Mao Xing-Gang, Weingart Melanie, Chu Qian, Rodriguez Fausto J, Eberhart Charles G, Raabe Eric H

Abstract excerpt

Glioblastoma (GBM) contains a population of stem-like cells that promote tumor invasion and resistance to therapy. Identifying and targeting stem cell factors in GBM may lead to the development of more effective therapies. High Mobility Group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in normal and cancer stem cells. We identified increased expression of HMGA2 in the...

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AC133 Antigen
Glioblastoma
HMGA2 Protein
Neoplasm Invasiveness
Neoplastic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spheroids, Cellular

Xenograft Model Antitumor Assays

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Identifiers

PMID: 27102002
DOI: 10.1016/j.canlet.2016.04.020
PMCID: PMC5091648

Genes

HMGA2

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