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Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma

30 May 2013

Abstract excerpt

Tumor cell plasticity contributes to functional and morphologic heterogeneity. To uncover the underlying mechanisms of this plasticity, we examined glioma stem-like cells (GSC) where we found that the biologic interconversion between GSCs and differentiated non-GSCs is functionally plastic and accompanied by gain or loss of polycomb repressive complex 2 (PRC2), a complex that modifies chromatin structure. PRC2...

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PMID: 23720055
DOI: 10.1158/0008-5472.can-13-0109

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