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Article

The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo

14 Jun 2013

Abstract excerpt

The Janus kinase (JAK)-inhibitor ruxolitinib decreases constitutional symptoms and spleen size of myelofibrosis (MF) patients by mechanisms distinct from its anticlonal activity. Here we investigated whether ruxolitinib affects dendritic cell (DC) biology. The in vitro development of monocyte-derived DCs was almost completely blocked when the compound was added throughout the differentiation period. Furthermore,...

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PMID: 23770777
DOI: 10.1182/blood-2013-03-484642

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