Article

Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapy

2022-06-26

Abstract excerpt

Unleashing anti-tumor T cell activity by checkpoint inhibition is effective in many cancer patients but clinical response rates remain limited. Myeloid derived suppressor cells erode antitumor lymphocyte numbers and function, and correlate with resistance to checkpoint inhibitors. By screening small molecule libraries, we identified JAK inhibitors’ ability to rescue T cell function. Despite its documented immune s...

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Literature Corpus work: ff3b2570-0eda-574f-b060-1c318883662c
DOI: 10.1101/2022.06.24.497435

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