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Article

RAD001-mediated mTOR targeting in human monocyte-derived dendritic cells shifts them toward an immunogenic phenotype.

Immunologic research - 19 Dec 2024

Naseri Bahar, Alipour Shiva, Masoumi Javad, Hatami-Sadr Amirhossein, Vaysi Edris, Hemmat Nima, Alizadeh Nazila, Baradaran Behzad

Abstract excerpt

Dendritic cells (DCs) are essential for promoting T lymphocyte responses since they are specialist antigen-presenting cells. In order to maintain tolerance or initiate immune responses, DCs must be activated in a balanced and regulated manner via diverse signaling pathways. By using a variety of pharmacological components, we can interfere with their different signaling pathways such as the mammalian target of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39699830
DOI: 10.1007/s12026-024-09572-8

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TNF

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