Article
The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.
Transplantation proceedings - 1 Jun 2009
Hou J, Wei J-M, Yu Z-Y, Xu Y, Li J, Tang D N
Abstract excerpt
BACKGROUND: FK778, a malononitrilamide analogue of lefunomide, is currently a promising immunosuppressive drug. Because the cellular and molecular mechanisms underlying the effects of FK778 are not entirely clarified. We studied its effects on human peripheral dendritic cells. METHODS: Peripheral blood mononuclear cells (PBMC) from 12 healthy volunteers were isolated by density separation over Ficoll solution....
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