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Janus kinase inhibitors alter NK cell phenotypes and inhibit their antitumour capacity.

Rheumatology (Oxford, England) - 1 Aug 2023

Meudec Loïc, Richebé Pauline, Pascaud Juliette, Mariette Xavier, Nocturne Gaetane

Abstract excerpt

OBJECTIVE: Janus kinase inhibitors (JAKi) are efficacious in RA but concerns regarding the risk of cancer associated with their exposure have recently emerged. Given the role of NK cells in antitumour response, we investigated the impact of JAKi [tofacitinib (TOFA), baricitinib (BARI), upadacitinib (UPA) and filgotinib (FIL)] on NK cells. METHODS: We first performed an ex vivo phenotype of NK cells in RA patients...

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PMID: 36583542
DOI: 10.1093/rheumatology/keac710

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