Article
Efficacy of ruxolitinib for myelofibrosis.
Expert opinion on pharmacotherapy - 1 Jul 2014
Santos Fabio P S, Verstovsek Srdan
Abstract excerpt
INTRODUCTION: The discovery of the activating JAK2 V617F mutation in patients with myelofibrosis (MF) led to the development of JAK2 inhibitors. The first such inhibitor to enter clinical trials was ruxolitinib . This review summarizes preclinical and clinical data of ruxolitinib in MF. AREAS COVERED: A literature search through Medline employing the terms 'ruxolitinib,' 'INCB018424' and 'myelofibrosis' was...
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