Article
Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.
Cell cycle (Georgetown, Tex.) - 1 Apr 2006
McDonald Stuart A C, Preston Sean L, Greaves Laura C, Leedham Simon J, Lovell Matthew A, Jankowski Janusz A Z, Turnbull Douglass M, Wright Nicholas A
Abstract excerpt
The mechanisms of how DNA mutations are fixed within the human gastrointestinal tract and how they spread are poorly understood and are hotly debated. It has been well documented that human colonic crypts are clonal units; one epithelial stem cell within the crypt becoming dominant and taking over the crypts' entire stem cell population--so called monoclonal conversion. Studies have revealed that crypts can exist...
Topics
- Colon
- DNA, Mitochondrial
- Electron Transport Complex IV
- Gastrointestinal Tract
- Gene Expression Regulation, Neoplastic
- Humans
- Models, Biological
- Models, Genetic
- Mutation
- Phenotype