Article
Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.
The Journal of pathology - 1 Mar 2009
Gutierrez-Gonzalez Lydia, Deheragoda Maesha, Elia George, Leedham Simon J, Shankar Arjun, Imber Charles, Jankowski Janusz A, Turnbull Douglass M, Novelli Marco, Wright Nicholas A, McDonald Stuart A C
Abstract excerpt
Little is known about the clonal structure or stem cell architecture of the human small intestinal crypt/villus unit, or how mutations spread and become fixed. Using mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion of stem cell progeny, we aimed to provide answers to these questions. Enzyme histochemistry (for cytochrome c oxidase and succinate dehydrogenase) was performed on frozen sections of...
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