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Article

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.

Gut - 1 Oct 2012

Nicholson Anna M, Graham Trevor A, Simpson Ashley, Humphries Adam, Burch Nicola, Rodriguez-Justo Manuel, Novelli Marco, Harrison Rebecca, Wright Nicholas A, McDonald Stuart A C, Jankowski Janusz A

Abstract excerpt

BACKGROUND: Little is known about the stem cell organisation of the normal oesophagus or Barrett's metaplastic oesophagus. Using non-pathogenic mitochondrial DNA mutations as clonal markers, the authors reveal the stem cell organisation of the human squamous oesophagus and of Barrett's metaplasia and determine the mechanism of clonal expansion of mutations. METHODS: Mutated cells were identified using enzyme...

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Identifiers

PMID: 22200839
DOI: 10.1136/gutjnl-2011-301174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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