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Article

PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks.

Cell reports - 29 Oct 2019

Álvarez Vanesa, Frattini Camilla, Sacristán María P, Gallego-Sánchez Alfonso, Bermejo Rodrigo, Bueno Avelino

Abstract excerpt

DNA damage tolerance plays a key role in protecting cell viability through translesion synthesis and template switching-mediated bypass of genotoxic polymerase-blocking base lesions. Both tolerance pathways critically rely on ubiquitylation of the proliferating-cell nuclear antigen (PCNA) on lysine 164 and have been proposed to operate uncoupled from replication. We report that Ubp10 and Ubp12 ubiquitin proteases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31665643
DOI: 10.1016/j.celrep.2019.09.054

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