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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

12 Jul 2022

Abstract excerpt

Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymerase REV1. The division of labor between PCNA-ubiquitination and REV1 in interstrand crosslink repair is unclear. Inhibition of either of these pathways has been...

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PMID: 35819193
DOI: 10.1093/nar/gkac545

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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicinePMID 35819193Read ↗

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