Article
Functional interaction between SNPs and microsatellite in the transcriptional regulation of insulin-like growth factor 1.
Human mutation - 1 Sept 2013
Chen Holly Y, Huang Wei, Leung Vincent H K, Fung Simon L M, Ma Suk Ling, Jiang Hongling, Tang Nelson L S
Abstract excerpt
A CA-repeat microsatellite in insulin-like growth factor 1 (IGF1) promoter was associated with interindividual variation of circulating IGF1 level. Previously, we reported that such association was due to variation of haplotype unit in a linkage disequilibrium block composed of microsatellite and single-nucleotide polymorphisms (SNPs), suggesting the presence of an interaction between them. In this study,...
Topics
- Base Sequence
- Gene Expression Regulation
- Genetic Variation
- Genome, Human
- Haplotypes
- Humans
- Insulin-Like Growth Factor I
- Linkage Disequilibrium
- Microsatellite Repeats
- Molecular Sequence Data