Article
Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.
Experimental gerontology - 1 Oct 2008
Xie Liang, Gong Yuan-ying, Lian Shi-gang, Yang Juan, Yang Ya, Gao Shou-jun, Xu Liang-you, Zhang Ya-ping
Abstract excerpt
Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential role of the promoter region variation of IGF-1 gene in longevity, we investigated 485 longevity...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- China
- Female
- Genotype
- Humans
- Insulin-Like Growth Factor I
- Linkage Disequilibrium
- Longevity