Article
The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model.
Scientific reports - 2 Dec 2016
Chen Holly Y, Ma Suk Ling, Huang Wei, Ji Lindan, Leung Vincent H K, Jiang Honglin, Yao Xiaoqiang, Tang Nelson L S
Abstract excerpt
Functional short tandem repeats (STR) are polymorphic in the population, and the number of repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR in IGF1 promoter has been extensively studied for its association with IGF1 concentration in blood and various clinical traits and represents an important eSTR. We previously used an in-vitro luciferase reporter model to examine the...
Topics
- Cell Line
- Humans
- Insulin-Like Growth Factor I
- Microsatellite Repeats
- Nucleotide Motifs
- Polymorphism, Single Nucleotide
- Response Elements
- Transcription, Genetic
- Transcriptional Activation