Article
Some microsatellites may act as novel polymorphic cis-regulatory elements through transcription factor binding.
Gene - 27 Oct 2004
Iglesias Alvaro Rada, Kindlund Ellen, Tammi Martti, Wadelius Claes
Abstract excerpt
Although microsatellites with functional effects have been described, generally, these repeats are considered as "junk" DNA in the same way as other repetitive sequences. Our aim was to investigate if certain microsatellites can have a functional role as cis-regulatory elements. A database was created of all short tandem repeats, from 2 to 10 bases, located in the first 10-kb 5' of the transcription start sites...
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