Article
Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes.
Biochemical and biophysical research communications - 12 Sept 2008
Lv Ke, Guo Yingjun, Zhang Yiliang, Wang Kaiyu, Jia Yin, Sun Shuhan
Abstract excerpt
The biological mechanism of a recent discovered association of type 2 diabetes with the ACAA-insertion/deletion polymorphism at the 3'UTR of the IGF2R gene has remained unclear. A very recently emerging novel polymorphic control layer by microRNAs (miRNAs) makes it possible to elucidate this issue. In this study, a prediction by web tools MicroInspector and miRanda demonstrated that DNA sequence polymorphism...
Topics
- 3' Untranslated Regions
- Alleles
- Binding Sites
- Cell Line
- Computational Biology
- Diabetes Mellitus, Type 2
- Gene Expression Regulation
- Humans
- MicroRNAs
- Mutagenesis, Insertional
- Polymorphism, Genetic
- Receptor, IGF Type 2
- Sequence Deletion