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Article

Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice.

Journal of atherosclerosis and thrombosis - 1 Jan 2012

Kitagaki Manabu, Isoda Kikuo, Kamada Haruhiko, Kobayashi Takayuki, Tsunoda Shinichi, Tsutsumi Yasuo, Niida Tomiharu, Kujiraoka Takehiko, Ishigami Norio, Ishihara Miya, Matsubara Osamu, Ohsuzu Fumitaka, Kikuchi Makoto

Abstract excerpt

AIM: Tumor necrosis factor receptor 1 (TNFR1) participates importantly in arterial inflammation in genetically altered mice; however it remains undetermined whether a selective TNFR1 antagonist inhibits arterial inflammation and intimal hyperplasia. This study aimed to determine the effect and mechanism of a novel TNFR1 antagonist in the suppression of arterial inflammation. METHODS: We investigated intimal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22146239
DOI: 10.5551/jat.9746

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TNF

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