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Article

Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.

Nature communications - 16 Oct 2017

Krishnasamy Kashyap, Limbourg Anne, Kapanadze Tamar, Gamrekelashvili Jaba, Beger Christian, Häger Christine, Lozanovski Vladimir J, Falk Christine S, Napp L Christian, Bauersachs Johann, Mack Matthias, Haller Hermann, Weber Christian, Adams Ralf H, Limbourg Florian P

Abstract excerpt

Ischemia causes an inflammatory response that is intended to restore perfusion and homeostasis yet often aggravates damage. Here we show, using conditional genetic deletion strategies together with adoptive cell transfer experiments in a mouse model of hind limb ischemia, that blood vessels control macrophage differentiation and maturation from recruited monocytes via Notch signaling, which in turn promotes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29038527
DOI: 10.1038/s41467-017-00953-2
PMCID: PMC5643305

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