Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.

Oncogene - 22 May 2014

Sangar F, Schreurs A-S, Umaña-Diaz C, Clapéron A, Desbois-Mouthon C, Calmel C, Mauger O, Zaanan A, Miquel C, Fléjou J-F, Praz F

Abstract excerpt

Small ArfGAP1 (stromal membrane-associated protein 1, SMAP1), a GTPase-activating protein specific for ADP-ribosylation factor 6 (Arf6), which is a small GTPase acting on membrane trafficking and actin remodeling, is frequently mutated in various tumors displaying microsatellite instability (MSI), notably in MSI colorectal cancers (CRC). Genotyping of 93 MSI CRCs (40 stage II, 32 stage III and 21 stage IV)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 6
Share to ADP-Ribosylation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTPase-Activating Proteins

Share to HCT116 Cells

Share to Neoplasm Transplantation

Share to Snail Family Transcription Factors

Share to Tumor Burden

Share to Vimentin

Source

Identifiers

PMID: 23752192
DOI: 10.1038/onc.2013.211

Genes

SMAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.PMID 23752192Read ↗

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.Semantic proximity Read ↗

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.Semantic proximity Read ↗

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.Semantic proximity Read ↗

Loss of INI1 expression in colorectal carcinoma is associated with high tumor grade, poor survival, BRAFV600E mutation, and mismatch repair deficiency.Semantic proximity Read ↗

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.Semantic proximity Read ↗

RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.Semantic proximity Read ↗

RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner.Semantic proximity Read ↗

Brush border myosin Ia has tumor suppressor activity in the intestine.Semantic proximity Read ↗

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.Semantic proximity Read ↗

Direct interaction with and activation of p53 by SMAR1 retards cell‐cycle progression at G<sub>2</sub>/M phase and delays tumor growth in miceSemantic proximity Read ↗

Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancerSemantic proximity Read ↗

CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.