Brush border myosin Ia has tumor suppressor activity in the intestine.

doi:10.1073/pnas.1108411109

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Article

Brush border myosin Ia has tumor suppressor activity in the intestine.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2012

Mazzolini Rocco, Dopeso Higinio, Mateo-Lozano Silvia, Chang Wakam, Rodrigues Paulo, Bazzocco Sarah, Alazzouzi Hafid, Landolfi Stefania, Hernández-Losa Javier, Andretta Elena, Alhopuro Pia, Espín Eloy, Armengol Manel, Tabernero Josep, Ramón y Cajal Santiago, Kloor Matthias, Gebert Johannes, Mariadason John M, Schwartz Simo, Aaltonen Lauri A, Mooseker Mark S, Arango Diego

Abstract excerpt

The loss of the epithelial architecture and cell polarity/differentiation is known to be important during the tumorigenic process. Here we demonstrate that the brush border protein Myosin Ia (MYO1A) is important for polarization and differentiation of colon cancer cells and is frequently inactivated in colorectal tumors by genetic and epigenetic mechanisms. MYO1A frame-shift mutations were observed in 32% (37 of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22307608
DOI: 10.1073/pnas.1108411109
PMCID: PMC3277176

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