Article
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
Cancer research - 1 Apr 2016
Lee Min-Goo, Jeong Seong-In, Ko Kyung-Phil, Park Soon-Ki, Ryu Byung-Kyu, Kim Ick-Young, Kim Jeong-Kook, Chi Sung-Gil
Abstract excerpt
RASSF1A is a tumor suppressor implicated in many tumorigenic processes; however, the basis for its tumor suppressor functions are not fully understood. Here we show that RASSF1A is a novel antagonist of protumorigenic RhoA activity. Direct interaction between the C-terminal amino acids (256-277) of RASSF1A and active GTP-RhoA was critical for this antagonism. In addition, interaction between the N-terminal amino...
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