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Article

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.

Cancer research - 1 Apr 2011

Vilar Eduardo, Bartnik Catherine M, Stenzel Stephanie L, Raskin Leon, Ahn Jaeil, Moreno Victor, Mukherjee Bhramar, Iniesta Maria D, Morgan Meredith A, Rennert Gad, Gruber Stephen B

Abstract excerpt

Microsatellite instability (MSI) is displayed by approximately 15% of colorectal cancers (CRC). Defective DNA mismatch repair generates mutations at repetitive DNA sequences such as those located in the double strand break (DSB) repair gene MRE11. We assessed the mutational status of MRE11 in a panel of 17 CRC cell lines and 46 primary tumors and found a strong correlation with MSI status in both cell lines and...

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Source

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Identifiers

PMID: 21300766
DOI: 10.1158/0008-5472.CAN-10-1120
PMCID: PMC3407272

Genes

MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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