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Article

RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner.

Cell death & disease - 14 Oct 2020

Liang Ying-Ying, Deng Xu-Bin, Lin Xian-Tao, Jiang Li-Li, Huang Xiao-Ting, Mo Zhi-Wen, Yuan Ya-Wei, Teh Muy-Teck

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or underlying mechanism of RASSF1A on the malignant phenotype. In the present study, we observed...

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Identifiers

PMID: 33057010
DOI: 10.1038/s41419-020-03054-z
PMCID: PMC7560678

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