Article
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.
International journal of cancer - 1 Aug 2014
Cajuso Tatiana, Hänninen Ulrika A, Kondelin Johanna, Gylfe Alexandra E, Tanskanen Tomas, Katainen Riku, Pitkänen Esa, Ristolainen Heikki, Kaasinen Eevi, Taipale Minna, Taipale Jussi, Böhm Jan, Renkonen-Sinisalo Laura, Mecklin Jukka-Pekka, Järvinen Heikki, Tuupanen Sari, Kilpivaara Outi, Vahteristo Pia
Abstract excerpt
ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene family, which comprises of 15 genes involved, for example, in transcriptional regulation, proliferation and chromatin remodeling. In this study, we used exome sequencing data to analyze the mutation frequency of all the ARID domain...
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