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Article

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Molecular microbiology - 1 Aug 2013

Fang Wenxia, Du Ting, Raimi Olawale G, Hurtado-Guerrero Ramon, Urbaniak Michael D, Ibrahim Adel F M, Ferguson Michael A J, Jin Cheng, van Aalten Daan M F

Abstract excerpt

The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor for the synthesis of chitin, an essential component of the fungal cell wall. UDP-N-acetylglucosamine pyrophosphorylase (UAP) is the final enzyme in eukaryotic UDP-GlcNAc biosynthesis, converting UTP and N-acetylglucosamine-1-phosphate (GlcNAc-1P) to UDP-GlcNAc. As...

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Identifiers

PMID: 23750903
DOI: 10.1111/mmi.12290
PMCID: PMC3888555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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