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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen <i>Cryptococcus neoformans</i>

2024-05-20

Abstract excerpt

Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. Rtf1 is stably associated with the Paf1C in Saccharomyces cerevisiae , but not in other species including humans. Little is known about its function in human fungal pathogens. Here, we show that Rtf1 is required for facilitat...

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Identifiers and source

Literature Corpus work
1447f1cc-9d41-5b02-bf90-8d197787feef
DOI
10.1101/2024.05.20.594937
Open publication

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