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Article

The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence.

Journal of bacteriology - 1 Jun 1998

Tsai H F, Chang Y C, Washburn R G, Wheeler M H, Kwon-Chung K J

Abstract excerpt

Aspergillus fumigatus, an important opportunistic pathogen which commonly affects neutropenic patients, produces conidia with a bluish-green color. We identified a gene, alb1, which is required for conidial pigmentation. The alb1 gene encodes a putative polyketide synthase, and disruption of alb1 resulted in an albino conidial phenotype. Expression of alb1 is developmentally regulated, and the 7-kb transcript is...

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Identifiers

PMID: 9620950
DOI: 10.1128/JB.180.12.3031-3038.1998
PMCID: PMC107801

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