Article

Targeting a critical step in fungal hexosamine biosynthesis

2020-01-08

Abstract excerpt

<h4>Summary</h4> Aspergillus fumigatus is a human opportunistic fungal pathogen with a cell wall that protects it from the extracellular environment. Chitin, an essential cell wall component, is synthesised from UDP-GlcNAc that is produced by the hexosamine biosynthetic pathway. Here, we provide genetic and chemical evidence that glucosamine 6-phosphate N -acetyltransferase (Gna1), a key enzyme in this pathway,...

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Literature Corpus work: 6a8a4077-3de9-5360-898a-64bc9922eb87
DOI: 10.1101/2020.01.07.896944

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