Article
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Mar 2012
Gokhale Avanti, Larimore Jennifer, Werner Erica, So Lomon, Moreno-De-Luca Andres, Lese-Martin Christa, Lupashin Vladimir V, Smith Yoland, Faundez Victor
Abstract excerpt
The Biogenesis of Lysosome-Related Organelles Complex 1 (BLOC-1) is a protein complex containing the schizophrenia susceptibility factor dysbindin, which is encoded by the gene DTNBP1. However, mechanisms engaged by dysbindin defining schizophrenia susceptibility pathways have not been quantitatively elucidated. Here, we discovered prevalent and novel cellular roles of the BLOC-1 complex in neuronal cells by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.