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Article

Regulatory T cells improve nephrocalcinosis but not dystrophic cardiac calcinosis in DBA/2 mice.

The American journal of pathology - 1 Aug 2013

Kirsch Alexander H, Smaczny Nicole, Riegelbauer Viktoria, Sedej Simon, Hofmeister Alexander, Stojakovic Tatjana, Goessler Walter, Brodmann Marianne, Pilger Ernst, Rosenkranz Alexander R, Eller Kathrin, Eller Philipp

Abstract excerpt

Nephrocalcinosis is characterized by aberrant deposition of calcium in the kidneys and is seen in phosphate nephropathy, primary hyperparathyroidism, and distal renal tubular acidosis. To further evaluate the specific pathophysiologic role of T cells in ectopic calcification, we used DBA/2 mice that are prone to develop nephrocalcinosis and dystrophic cardiac calcinosis. Female DBA/2 mice were depleted of T cells...

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PMID: 23746654
DOI: 10.1016/j.ajpath.2013.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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