Article
Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease.
Kidney international - 1 Oct 2013
Lu Junyu, Cao Qi, Zheng Dong, Sun Yan, Wang Changqi, Yu Xiao, Wang Ya, Lee Vincent W S, Zheng Guoping, Tan Thian K, Wang Xin, Alexander Stephen I, Harris David C H, Wang Yiping
Abstract excerpt
Two types of alternatively activated macrophages, M(2a) induced by IL-4/IL-13 and M(2c) by IL-10/TGF-β, exhibit anti-inflammatory functions in vitro and protect against renal injury in vivo. Since their relative therapeutic efficacy is unclear, we compared the effects of these two macrophage subsets in murine adriamycin nephrosis. Both subsets significantly reduced renal inflammation and renal injury; however,...
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