The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

doi:10.1038/ncomms2968

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Nature communications - 1 Jan 2013

Müller Timo D, Müller Anne, Yi Chun-Xia, Habegger Kirk M, Meyer Carola W, Gaylinn Bruce D, Finan Brian, Heppner Kristy, Trivedi Chitrang, Bielohuby Maximilian, Abplanalp William, Meyer Franziska, Piechowski Carolin L, Pratzka Juliane, Stemmer Kerstin, Holland Jenna, Hembree Jazzmin, Bhardwaj Nakul, Raver Christine, Ottaway Nickki, Krishna Radha, Sah Renu, Sallee Floyd R, Woods Stephen C, Perez-Tilve Diego, Bidlingmaier Martin, Thorner Michael O, Krude Heiko, Smiley David, DiMarchi Richard, Hofmann Susanna, Pfluger Paul T, Kleinau Gunnar, Biebermann Heike, Tschöp Matthias H

Abstract excerpt

The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 is regulated in response to nutrient availability and is decreased in obese mice compared with lean mice. In the arcuate nucleus, Gpr83...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agouti-Related Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Composition

Share to Diet, High-Fat

Share to Feeding Behavior

Share to Ghrelin

Share to Receptor, Melanocortin, Type 3

Share to Receptors, G-Protein-Coupled

Share to Receptors, Ghrelin

Source

Open in PubMed Open full text

Identifiers

PMID: 23744028
DOI: 10.1038/ncomms2968
PMCID: PMC3709495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23744028-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.PMID 23744028Read ↗

The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.Semantic proximity Read ↗

Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82.Semantic proximity Read ↗

The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake.Semantic proximity Read ↗

Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.Semantic proximity Read ↗

Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.Semantic proximity Read ↗

Beyond Hunger: Structure, Signaling and Systemic Roles of GhrelinSemantic proximity Read ↗

Metabolic insights from a GHSR-A203E mutant mouse model.Semantic proximity Read ↗

Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.Semantic proximity Read ↗

The role of the Agouti-Related Protein in energy balance regulation.Semantic proximity Read ↗

GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein.Semantic proximity Read ↗

microRNA-33 controls hunger signaling in hypothalamic AgRP neuronsSemantic proximity Read ↗

Mice lacking ghrelin receptors resist the development of diet-induced obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.