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Article

Metabolic insights from a GHSR-A203E mutant mouse model.

Molecular metabolism - 1 Sept 2020

Torz Lola J, Osborne-Lawrence Sherri, Rodriguez Juan, He Zhenyan, Cornejo María Paula, Mustafá Emilio Román, Jin Chunyu, Petersen Natalia, Hedegaard Morten A, Nybo Maja, Damonte Valentina Martínez, Metzger Nathan P, Mani Bharath K, Williams Kevin W, Raingo Jesica, Perello Mario, Holst Birgitte, Zigman Jeffrey M

Abstract excerpt

OBJECTIVE: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as suggested by findings in short people with naturally occurring GHSR-A204E mutations and reduced food intake and blood glucose in rodents administered GHSR...

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Identifiers

PMID: 32339772
DOI: 10.1016/j.molmet.2020.101004
PMCID: PMC7242877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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