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Article

The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.

BMC research notes - 16 Dec 2014

Müller Anne, Leinweber Brinja, Fischer Jana, Müller Timo D, Grüters Annette, Tschöp Matthias H, Knäuper Vera, Biebermann Heike, Kleinau Gunnar

Abstract excerpt

BACKGROUND: Recently, the orphan G-protein coupled receptor 83 (GPR83) was identified as a new participant in body weight regulation. This receptor is highly expressed in the hypothalamic arcuate nucleus and is regulated in response to nutrient availability. Gpr83 knock-out mice are protected fro...

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Source

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Identifiers

PMID: 25516095
DOI: 10.1186/1756-0500-7-913
PMCID: PMC4300838

Genes

GPR83

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25516095-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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