Article
Recognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation.
FEBS letters - 11 Jul 2013
Bañuelos Sonia, Lectez Benoît, Taneva Stefka G, Ormaza Georgina, Alonso-Mariño Marián, Calle Xabier, Urbaneja María A
Abstract excerpt
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome biogenesis. NPM1 gene is frequently mutated in acute myeloid leukaemia (AML), correlating with aberrant cytoplasmic localization of the protein. NPM attachment to the nucleolus in physiological conditions probably depends on binding...
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