Article
AML-associated mutation of nucleophosmin compromises its interaction with nucleolin.
The international journal of biochemistry & cell biology - 1 Oct 2018
Šašinková Markéta, Holoubek Aleš, Otevřelová Petra, Kuželová Kateřina, Brodská Barbora
Abstract excerpt
C-terminal mutations of the nucleolar protein nucleophosmin (NPM) are the most frequent genetic aberration detected in acute myeloid leukemia (AML) with normal karyotype. The mutations cause aberrant cytoplasmic localization of NPM and lead to loss of functions associated with NPM nucleolar localization, e.g. in ribosome biogenesis or DNA-damage repair. NPM has many interaction partners and some of them were...
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