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Article

Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.

Neurobiology of disease - 1 Oct 2013

Morice Elise, Farley Séverine, Poirier Roseline, Dallerac Glenn, Chagneau Carine, Pannetier Solange, Hanauer André, Davis Sabrina, Vaillend Cyrille, Laroche Serge

Abstract excerpt

The Coffin-Lowry syndrome (CLS) is a syndromic form of intellectual disability caused by loss-of-function of the RSK2 serine/threonine kinase encoded by the rsk2 gene. Rsk2 knockout mice, a murine model of CLS, exhibit spatial learning and memory impairments, yet the underlying neural mechanisms are unknown. In the current study, we examined the performance of Rsk2 knockout mice in cued, trace and contextual fear...

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Identifiers

PMID: 23742761
DOI: 10.1016/j.nbd.2013.05.016

Genes

EGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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