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Article

Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons.

Disease models & mechanisms - 1 Nov 2015

Beck Katherina, Ehmann Nadine, Andlauer Till F M, Ljaschenko Dmitrij, Strecker Katrin, Fischer Matthias, Kittel Robert J, Raabe Thomas

Abstract excerpt

Plastic changes in synaptic properties are considered as fundamental for adaptive behaviors. Extracellular-signal-regulated kinase (ERK)-mediated signaling has been implicated in regulation of synaptic plasticity. Ribosomal S6 kinase 2 (RSK2) acts as a regulator and downstream effector of ERK. In the brain, RSK2 is predominantly expressed in regions required for learning and memory. Loss-of-function mutations in...

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Source

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Identifiers

PMID: 26398944
DOI: 10.1242/dmm.021246
PMCID: PMC4631788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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